Gloria Huei-Ting Su, Ph.D.

Publications

1. G. H. Su, W. Hilgers, M. C. Sheker, D. J. Tang, C. J. Yeo, R. H. Hruban, S. E. Kern.  Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.  Cancer Research 1998; 58:2339-2342

2. G. H. Su, R. H. Hruban, R. K. Bansal, G. S. Bova, D. J. Tang, M. C. Sheker, A. M. Westerman, M. M. Entius, M. Goggins, C. J. Yeo, S. E. Kern.  Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers.  American Journal of Pathology 1999; 154:1835-1840

3. W. Hilgers, G. H. Su, B. G. Koerkamp, D. J. Tang, M. C. Shekher, A. Y. Sugar, C. J. Yeo, R. H. Hruban, S. E. Kern.  Novel homozygous deletions of chromosomal band 18q22 in pancreatic adenocarcinoma identified by STS marker scanning.  Genes Chromosomes Cancer 1999; 25:370-375. 

4. R. E. Wilentz, G. H. Su, J. L. Dai, A. B. Sparks, P. Argani, T. A. Sohn, C. J. Yeo, S. E. Kern, R. H. Hruban.  Immunohistochemical labeling for Dpc4 mirrors genetic status in pancreatic and peripancreatic adenocarcinomas: a new marker of DPC4 inactivation. American Journal of Pathology 2000, 156:37-43.

5. G. H. Su, T. A. Sohn, B. Ryu, S. E. Kern.  A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.  Cancer Research 2000, 60:3137-42. 

6. G. H. Su, R. Bansal, K. M. Murphy, E. Montgomery, C. J. Yeo, R. H. Hruban, S. E. Kern. ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma.  Proc. Natl. Acad. Sci. USA 2001, 98: 3254-7.

7. P. Argani, A. Shaukat, M. Kaushal, R. E. Wilentz, G. H. Su, T. A. Sohn, C. J. Yeo, J. L. Cameron, S. E. Kern, R. H. Hruban.  Biologic distinctions among carcinomas of the proximal and distal bile ducts evidenced by differing rates of loss of Dpc4 expression and of p53 overexpression.  Cancer 2001, 91:1332-41.

8. T. A. Sohn, G. H. Su, B. Ryu, C. J. Yeo, S. E. Kern.  High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells.  Annals of Surgery 2001, 233: 696-703.

9. G. H. Su, J. J. Song, E. A. Repasky, M. Schutte, S. E. Kern.  Mutation fate of MAP2K4/MKK4 in breast carcinoma.  Human Mutation 2002, 19:81.

10. T. A. Sohn, R. Bansal, G. H. Su, K. M. Murphy, S. E. Kern.  The interface of chemical space with the p53 functional universe.  Carcinogenesis 2002, 23:949-58. 

11. N. Sato, N. Maehara, G. H. Su, M. Goggins.  Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness.  JNCI 2003, 95:327-30.

12. F. Sahin, A. Maitra, P. Argani, N. Sato, N. Maehara, E. Montgomery, M. Goggins, R. H. Hruban, G. H. Su.  Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms.  Modern Pathology 22003, 16:686-91

13. N. Fukushima, N. Sato, F. Sahin, G. H. Su, R. H. Hruban, and M. Goggins.  Aberrant methylation of suppressor of cytokine signaling (SOCS-1) gene in pancreatic ductal neoplasms.  Br J Cancer 2003, 89:338-43.

14. N. Sato, N. Fukushima, N. Maehara, H. Matsubayashi, J. Koopmann, G. H. Su, R. H. Hruban, M. Goggins.  SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions.  Oncogene 2003, 22:5021-30.

15. H. Ghaffar, F. Sahin, M. Sanchez-Cepedes, G.H. Su, M. Zahurak, D. Sidransky, and W. H. Westra.  LKB1 Protein Expression in the Evolution of Glandular Neoplasia of the Lung.  2003, 9:2998-3003.

16. W. Qiu, R. Ashfaq, D. T. Dang, R. Wilentz, G. H. Su, and M. S. Torbenson.  Activation of the TGF-beta signaling pathway is associated with Bax protein over-expression in hepatocellular carcinoma.  Modern Pathology (Submitted).

17. A. R. Parker, R. N. O’Meally, F. Sahin, G. H. Su, W. G. Nelson, T. L. DeWeese, and J. R. Eshleman.  Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles.  J. Biol Chem 2003, 278:47937-45.

18. N. Fujiuchi, J. A. Aglipay, T. Ohtsuka, N. Maehara, F. Sahin, G. H. Su, S. W. Lee, T. Ouchi. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem. 2004, 279:20339-44.

19. R. Kannangai, F. Sahin, O. Adegbola, R. Ashfaq, G. H. Su, M. Torbenson. FHIT mRNA and protein expression in hepatocellular carcinoma. Mod Pathol. 2004, 17:653-9.

20. W. Xin, K. J. Yun, F. Ricci, M. Zahurak, W. Qiu, G. H. Su, C. J. Yeo, R. H. Hruban, S. E. Kern, C. A. Iacobuzio-Donahue.  MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course. Clin Cancer Res 2004, 10:8516-20.

21. G. S. Bova, I. A. Eltoum, J. A. Kiernan, G. P. Siegal, A. R. Frost, C. J. Best, J. W. Gillespie, G. H. Su, M. R. Emmert-Buck.  Optimal molecular profiling of tissue and tissue components: defining the best processing and microdissection methods for biomedical applications.  Mol Biotechnol. 2005, 29:119-52. 

22. F. Sahin, W. Qiu, R. E. Wilentz, C. A. Iacobuzio-Donahue, A. Grosmark, G. H. Su.  RPL38, FOSL1, and UPP1 are predominately expressed in the pancreatic ductal epithelium.  Pancreas 2005, 30:158-67. 

23. W. Qiu, F. Schönleben, H. M. Thaker, M. Goggins, G. H. Su.  A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma.  Oncogene 2006, 25:2937-42.

24. W. Qiu, , X. Li, D. J. Ho, L. G. Close, S. Manolidis, B. P. Bennett, G. H. Su.  PIK3CA mutations in head and neck squamous cell carcinoma.  Clinical Cancer Research 2006, 12:1441-6. 

25. W. Qiu, F. Schönleben, X. Li, G. H. Su.  Disruption of Transforming Growth Factor β–Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4.  Cancer Letter 2007 Jan 8;245(1-2):163-70. Epub 2006 Feb 14.

26. F. Schönleben, W. Qiu, N. T. Ciau, D. J. Ho, X. Li, J. D. Allendorf, H. E. Remotti, G. H. Su.  PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Clinical Cancer Research 2006, 12:3851-5.

27. H. Fenton, B. Carlile, E. A. Montgomery, H. Carraway, J. Herman, F. Sahin, G. H. Su, P. Argani.  LKB1 protein expression in human breast cancer.  Appl Immunohistochem Mol Morphol 2006, 14:146-53.   

28. F. Schönleben, W. Qiu, K. C. Bruckman, N. T. Ciau, X. Li, M. H. Lauerman, H. Frucht, J. A. Chabot, J. D. Allendorf, H. E. Remotti, G. H. Su.  BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Cancer Letters 2006 (Epub ahead of print).